{"data":{"7b958ce0-a727-9816-f2c8-548b54f39188":{"type":"Input[Set[Gene]]","value":{"description":"Example gene set","set":["ABCC9","ABCD4","ABL1","ACTB","ADAMTS10","ADK","AHDC1","ALDH18A1","ALKBH8","ARHGAP31","ARSK","ATIC","B3GALT6","B3GAT3","B3GLCT","BBS2","BCOR","BGN","BRAF","CAPN15","CCDC22","CCNQ","CDH2","CDK8","CEP57","CFAP53","CHD4","CHST3","CIROP","COQ4","CRELD1","CTCF","CTSA","DDX58","DHCR7","DPM2","DTNA","DYNC2LI1","EDNRA","EGFR","EIF5A","ELN","ENPP1","ERBB3","FBN1","FBN2","FGF23","FGFR1","FKTN","FLI1","FLNA","FOXF1","GATA4","GATA5","GATA6","GATAD2B","GDF1","GJA1","GJA5","GJA8","GLB1","GLI3","GNB2","GNPTG","HAAO","HCN4","HGD","HRAS","IDUA","IFIH1","IFT122","JAG1","KANSL1","KDM6A","KIF3B","KMT2D","KRAS","KYNU","LEMD2","LOX","LPA","LTBP2","LZTR1","MAP2K1","MAP3K7","MED12","MEIS2","MKKS","MKS1","MLXIPL","MYH11","MYH7","MYRF","NADSYN1","NFE2L2","NKX2-5","NOTCH1","NOTCH3","NR2F2","NRAS","NT5E","NUP188","NXN","PACS1","PAH","PCGF2","PKD1L1","POLR3GL","PPP1CB","PTPN11","RBM8A","RNU4ATAC","ROBO4","RPL26","RPS19","SGO1","SLC25A24","SLC29A3","SMAD2","SMAD4","SMAD6","SMO","SNIP1","SOS 2","SPOP","SRCAP","STAG2","STRA6","TAB2","TAF2","TALDO1","TBX1","TBX4","TBX5","TGDS","TGFB2","TGFBR1","TGFBR2","TMEM218","TNXB","TRAF7","TRRAP","UBE3B","UNC45B","WASHC5","WBP11","WDPCP","WT1"]}},"5ab5dec6-4057-944a-80e0-f9f654197336":{"type":"Set[Gene]","value":{"description":"Example gene set","set":["ABCC9","ABCD4","ABL1","ACTB","ADAMTS10","ADK","AHDC1","ALDH18A1","ALKBH8","ARHGAP31","ARSK","ATIC","B3GALT6","B3GAT3","B3GLCT","BBS2","BCOR","BGN","BRAF","CAPN15","CCDC22","CCNQ","CDH2","CDK8","CEP57","CFAP53","CHD4","CHST3","CIROP","COQ4","CRELD1","CTCF","CTSA","DDX58","DHCR7","DPM2","DTNA","DYNC2LI1","EDNRA","EGFR","EIF5A","ELN","ENPP1","ERBB3","FBN1","FBN2","FGF23","FGFR1","FKTN","FLI1","FLNA","FOXF1","GATA4","GATA5","GATA6","GATAD2B","GDF1","GJA1","GJA5","GJA8","GLB1","GLI3","GNB2","GNPTG","HAAO","HCN4","HGD","HRAS","IDUA","IFIH1","IFT122","JAG1","KANSL1","KDM6A","KIF3B","KMT2D","KRAS","KYNU","LEMD2","LOX","LPA","LTBP2","LZTR1","MAP2K1","MAP3K7","MED12","MEIS2","MKKS","MKS1","MLXIPL","MYH11","MYH7","MYRF","NADSYN1","NFE2L2","NKX2-5","NOTCH1","NOTCH3","NR2F2","NRAS","NT5E","NUP188","NXN","PACS1","PAH","PCGF2","PKD1L1","POLR3GL","PPP1CB","PTPN11","RBM8A","RNU4ATAC","ROBO4","RPL26","RPS19","SGO1","SLC25A24","SLC29A3","SMAD2","SMAD4","SMAD6","SMO","SNIP1","SOS 2","SPOP","SRCAP","STAG2","STRA6","TAB2","TAF2","TALDO1","TBX1","TBX4","TBX5","TGDS","TGFB2","TGFBR1","TGFBR2","TMEM218","TNXB","TRAF7","TRRAP","UBE3B","UNC45B","WASHC5","WBP11","WDPCP","WT1"]}},"87db27d3-b37c-db67-4dfb-a58343c0af2e":{"type":"CTDResponseInfo","value":{"highlyConnectedGenes":["map2k1","braf","kras","tgfb2","tgfbr2","tgfbr1","smad2","smad4","smad6"],"guiltyByAssociationGenes":["tgfb1","eng","tgfb3","smad7","smurf2","gdf2","smurf1"],"jsonGraph":{"nodes":[{"name":"tgfb1","type":"gene"},{"name":"tgfb3","type":"gene"},{"name":"kras","type":"gene"},{"name":"smad7","type":"gene"},{"name":"smad2","type":"gene"},{"name":"smurf2","type":"gene"},{"name":"braf","type":"gene"},{"name":"smad6","type":"gene"},{"name":"map2k1","type":"gene"},{"name":"smad4","type":"gene"},{"name":"tgfbr2","type":"gene"},{"name":"smurf1","type":"gene"},{"name":"tgfb2","type":"gene"},{"name":"eng","type":"gene"},{"name":"tgfbr1","type":"gene"},{"name":"gdf2","type":"gene"}],"interactions":[{"source":"tgfb1","target":"tgfb3"},{"source":"tgfb1","target":"kras"},{"source":"tgfb1","target":"smad7"},{"source":"tgfb1","target":"smad2"},{"source":"tgfb1","target":"smurf2"},{"source":"tgfb1","target":"smad6"},{"source":"tgfb1","target":"smad4"},{"source":"tgfb1","target":"tgfbr2"},{"source":"tgfb1","target":"smurf1"},{"source":"tgfb1","target":"tgfb2"},{"source":"tgfb1","target":"eng"},{"source":"tgfb1","target":"tgfbr1"},{"source":"tgfb3","target":"tgfb1"},{"source":"tgfb3","target":"smad7"},{"source":"tgfb3","target":"smad2"},{"source":"tgfb3","target":"smurf2"},{"source":"tgfb3","target":"smad6"},{"source":"tgfb3","target":"smad4"},{"source":"tgfb3","target":"tgfbr2"},{"source":"tgfb3","target":"smurf1"},{"source":"tgfb3","target":"tgfb2"},{"source":"tgfb3","target":"eng"},{"source":"tgfb3","target":"tgfbr1"},{"source":"kras","target":"tgfb1"},{"source":"kras","target":"smad2"},{"source":"kras","target":"braf"},{"source":"kras","target":"map2k1"},{"source":"kras","target":"smad4"},{"source":"kras","target":"tgfbr2"},{"source":"kras","target":"tgfbr1"},{"source":"smad7","target":"tgfb1"},{"source":"smad7","target":"tgfb3"},{"source":"smad7","target":"smad2"},{"source":"smad7","target":"smurf2"},{"source":"smad7","target":"smad6"},{"source":"smad7","target":"smad4"},{"source":"smad7","target":"tgfbr2"},{"source":"smad7","target":"smurf1"},{"source":"smad7","target":"tgfb2"},{"source":"smad7","target":"eng"},{"source":"smad7","target":"tgfbr1"},{"source":"smad7","target":"gdf2"},{"source":"smad2","target":"tgfb1"},{"source":"smad2","target":"tgfb3"},{"source":"smad2","target":"kras"},{"source":"smad2","target":"smad7"},{"source":"smad2","target":"smurf2"},{"source":"smad2","target":"smad6"},{"source":"smad2","target":"map2k1"},{"source":"smad2","target":"smad4"},{"source":"smad2","target":"tgfbr2"},{"source":"smad2","target":"smurf1"},{"source":"smad2","target":"tgfb2"},{"source":"smad2","target":"eng"},{"source":"smad2","target":"tgfbr1"},{"source":"smad2","target":"gdf2"},{"source":"smurf2","target":"tgfb1"},{"source":"smurf2","target":"tgfb3"},{"source":"smurf2","target":"smad7"},{"source":"smurf2","target":"smad2"},{"source":"smurf2","target":"smad6"},{"source":"smurf2","target":"smad4"},{"source":"smurf2","target":"tgfbr2"},{"source":"smurf2","target":"smurf1"},{"source":"smurf2","target":"tgfbr1"},{"source":"braf","target":"kras"},{"source":"braf","target":"map2k1"},{"source":"smad6","target":"tgfb1"},{"source":"smad6","target":"tgfb3"},{"source":"smad6","target":"smad7"},{"source":"smad6","target":"smad2"},{"source":"smad6","target":"smurf2"},{"source":"smad6","target":"smad4"},{"source":"smad6","target":"tgfbr2"},{"source":"smad6","target":"smurf1"},{"source":"smad6","target":"tgfb2"},{"source":"smad6","target":"eng"},{"source":"smad6","target":"tgfbr1"},{"source":"smad6","target":"gdf2"},{"source":"map2k1","target":"kras"},{"source":"map2k1","target":"smad2"},{"source":"map2k1","target":"braf"},{"source":"map2k1","target":"smad4"},{"source":"smad4","target":"tgfb1"},{"source":"smad4","target":"tgfb3"},{"source":"smad4","target":"kras"},{"source":"smad4","target":"smad7"},{"source":"smad4","target":"smad2"},{"source":"smad4","target":"smurf2"},{"source":"smad4","target":"smad6"},{"source":"smad4","target":"map2k1"},{"source":"smad4","target":"tgfbr2"},{"source":"smad4","target":"smurf1"},{"source":"smad4","target":"tgfb2"},{"source":"smad4","target":"eng"},{"source":"smad4","target":"tgfbr1"},{"source":"smad4","target":"gdf2"},{"source":"tgfbr2","target":"tgfb1"},{"source":"tgfbr2","target":"tgfb3"},{"source":"tgfbr2","target":"kras"},{"source":"tgfbr2","target":"smad7"},{"source":"tgfbr2","target":"smad2"},{"source":"tgfbr2","target":"smurf2"},{"source":"tgfbr2","target":"smad6"},{"source":"tgfbr2","target":"smad4"},{"source":"tgfbr2","target":"smurf1"},{"source":"tgfbr2","target":"tgfb2"},{"source":"tgfbr2","target":"eng"},{"source":"tgfbr2","target":"tgfbr1"},{"source":"tgfbr2","target":"gdf2"},{"source":"smurf1","target":"tgfb1"},{"source":"smurf1","target":"tgfb3"},{"source":"smurf1","target":"smad7"},{"source":"smurf1","target":"smad2"},{"source":"smurf1","target":"smurf2"},{"source":"smurf1","target":"smad6"},{"source":"smurf1","target":"smad4"},{"source":"smurf1","target":"tgfbr2"},{"source":"smurf1","target":"tgfbr1"},{"source":"tgfb2","target":"tgfb1"},{"source":"tgfb2","target":"tgfb3"},{"source":"tgfb2","target":"smad7"},{"source":"tgfb2","target":"smad2"},{"source":"tgfb2","target":"smad6"},{"source":"tgfb2","target":"smad4"},{"source":"tgfb2","target":"tgfbr2"},{"source":"tgfb2","target":"eng"},{"source":"tgfb2","target":"tgfbr1"},{"source":"eng","target":"tgfb1"},{"source":"eng","target":"tgfb3"},{"source":"eng","target":"smad7"},{"source":"eng","target":"smad2"},{"source":"eng","target":"smad6"},{"source":"eng","target":"smad4"},{"source":"eng","target":"tgfbr2"},{"source":"eng","target":"tgfb2"},{"source":"eng","target":"tgfbr1"},{"source":"eng","target":"gdf2"},{"source":"tgfbr1","target":"tgfb1"},{"source":"tgfbr1","target":"tgfb3"},{"source":"tgfbr1","target":"kras"},{"source":"tgfbr1","target":"smad7"},{"source":"tgfbr1","target":"smad2"},{"source":"tgfbr1","target":"smurf2"},{"source":"tgfbr1","target":"smad6"},{"source":"tgfbr1","target":"smad4"},{"source":"tgfbr1","target":"tgfbr2"},{"source":"tgfbr1","target":"smurf1"},{"source":"tgfbr1","target":"tgfb2"},{"source":"tgfbr1","target":"eng"},{"source":"tgfbr1","target":"gdf2"},{"source":"gdf2","target":"smad7"},{"source":"gdf2","target":"smad2"},{"source":"gdf2","target":"smad6"},{"source":"gdf2","target":"smad4"},{"source":"gdf2","target":"tgfbr2"},{"source":"gdf2","target":"eng"},{"source":"gdf2","target":"tgfbr1"}]},"report":null}},"aa2dcf65-80ea-a9fc-4092-f721bf902d48":{"type":"Set[Gene]","value":{"description":"Highly_Connected_Genes, CTD response","set":["map2k1","braf","kras","tgfb2","tgfbr2","tgfbr1","smad2","smad4","smad6"]}},"a9c88c0d-9e16-8116-c623-68c4284af472":{"type":"Set[Gene]","value":{"description":"Guilty_By_Association_Genes, CTD response","set":["tgfb1","eng","tgfb3","smad7","smurf2","gdf2","smurf1"]}}},"workflow":[{"id":"7b22b6d5-b5c9-c3c6-e913-2297f5aa0213","type":"Input[Set[Gene]]","data":{"id":"7b958ce0-a727-9816-f2c8-548b54f39188"},"output":{"id":"5ab5dec6-4057-944a-80e0-f9f654197336"}},{"id":"f20f2c57-ed3b-d5ae-f6f3-697a392beee2","type":"GeneSet_CTD_String","inputs":{"geneset":{"id":"7b22b6d5-b5c9-c3c6-e913-2297f5aa0213"}},"output":{"id":"87db27d3-b37c-db67-4dfb-a58343c0af2e"}},{"id":"d6847c31-6e2d-0b9c-886e-03b04329602b","type":"Highly_Connected_Genes","inputs":{"ctdResponseInfo":{"id":"f20f2c57-ed3b-d5ae-f6f3-697a392beee2"}},"output":{"id":"aa2dcf65-80ea-a9fc-4092-f721bf902d48"}},{"id":"40fa27f4-1df9-af74-9535-b4b7593f2c89","type":"Guilty_By_Association_Genes","inputs":{"ctdResponseInfo":{"id":"f20f2c57-ed3b-d5ae-f6f3-697a392beee2"}},"output":{"id":"a9c88c0d-9e16-8116-c623-68c4284af472"}}],"metadata":{"id":"d02a3634-df43-ee76-a23f-7f23b0a16138","title":"Use Case 10: Guilt by Association","description":"Given a set of genes, connect the dots (CTD) is performed against protein & pathway graphs to obtain a small subset of highly connected genes and those that are guilty by association.","summary":"auto","gpt_summary":""}}